One of my newest clients arrived at the office with reams of printouts in tow extolling the horrors of administering monthly poisons to protect our pets from heartworms. She also happened to live in the soggiest, boggiest part of Miami where mosquitoes are rumored to suck the life out of anything vaguely resembling a mammal.
Now, I’m not a big lover of poison therapies but, unfortunately, every “drug” I use is a toxin—it’s just a question of quantity. Sure, risk and reward factors into my use heavily. I’m not one to recommend a drug willy nilly. And pet parents are always granted leave to decline—though I’ll be sure to note on my medical records that they’ve done so…to cover my butt, of course.
(Last thing any vet wants is for their lax note-taking to land them in hot water when Humphrey gets heartworms over the next year. Nope. I’m not playing that game.)
I’m occasionally pooh-poohed by my veteran dog owners on what they perceive as the dubious merits of my heartworm prevention protocols. Based on their read of the literature, they’re often inclined to rely on the studies describing adverse reactions to ivermectin, milbemycin and selamectin (Heartgard, Interceptor and Revolution, respectively, the drugs we vets most commonly employ for parasite prevention).
And though these cases are by no means discountable out of hand, they represent just a tiny fraction of the millions of dogs who have received these meds over the past thirty years. More importantly, their cautionary numbers don’t measure up to the very real risk of heartworm disease—even among indoor pets.
Myth 1: My dog doesn’t need heartworm preventatives year-round because he lives where mosquitoes are rarely seen except in summer months.
If the ground doesn’t freeze solid where you live you likely need prevention year-round for 100% safety but it’s true that winter months offer a low, sometimes minuscule risk of infection.
Myth 2: My dog never goes outside so it’s pointless to give him these drugs.
Never? Doesn’t he need to go for a walk? Do you never see mosquitoes in your house? Ever? OK, then, for all of you living in condos in the Windy City where wee-wee pads reign supreme. You’re excused.
Myth 3: My cat doesn’t need heartworm preventatives because it’s rare in cats—and she doesn’t go outside anyway.
I’ve seen heartworm positives (antibody tests, which indicate exposure) in indoor cats. So far no antigen positives, but it’s a numbers game—eventually I’ll get one. In Florida, a at least, Heartworm’s not rare in cats.
Heartworm disease is still a real problem with serious consequences. Those heartworm preventative naysayers? They have a point. They're right to question the utility of ANY drug their pet consumes on a regular basis. But don't expect their vet to buck the establishment in ways that puts their hospital at risk, not when mosquitoes and their wily ways still manage to infect unsuspecting pets even in low-risk scenarios.
I know some of you won’t agree with me. So here’s a chance for you to ream me a new hole in my head through which your wise ideas might penetrate. Warning: My skull’s a bit thick on this issue so you’ll have to be very persuasive.
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My dogs get Interceptor year-round, my (exclusively indoor) cats do not. Here in PA the ground is mostly frozen from November through March at the very least. When heartworm moved northward from the South about 25 years ago, my vet recommended prevention during the warm months only, with an annual test in the spring before beginning the tablets. But after adopting a dog who had heartworm many years ago, and finding it to be Stage IV, supporting her through the treatment, and still watching her die of congestive heart failure from the residual damage, all my dogs are on continuous preventatives. But the incidence is still low enough here that I elect not use the drug in the cats. My vet says he has never seen a case of heartworm in an indoor cat here in PA in over thirty-five years of practice, though he has seen a couple cases in ferals or indoor-outdoor cats. We discuss this every year at the kitties' annual check-up (they're all young and healthy). If at any time he recommends beginning prevention for them, of course I would comply.
Shellie March 22nd, 2008 08:40:00 AM
I changed my heartworm protocols when we moved from Southern Maryland (swampy, low-lying, not a predictable period of yearly freeze) to Pennsylvania. I'm just about to talk to my vet about purchasing our first doses of the spring though. I always find myself poring over the various brands and combinations of things and I have to confess sometimes it gets confusing, between the heartworm pills and the various flea/tick treatments.
cressida March 22nd, 2008 09:30:00 AM
I've had dogs all my life (although in my young years they were the main responsibility of my mother), and I cannot recall a time in which they were not on year-round heartworm preventative. I've lived in both California and Texas. The first dogs I really remembered never had a problem with preventative, my parents' current dog has never had a problem, and the dog I have now hasn't either. I say better safe than sorry - the risks are so low that not giving them preventative is just asking for heartworm.
1st Year March 22nd, 2008 09:32:00 AM
I can not afford the Heartworm meds you mention so I use (off label) an alternative. I would prefer to use the ones specifically made for dogs in nice little treat like pills. I guess either their costs are significantly greater to make those (as opposed to what I use) or their greed is significantly greater than their desire to help animals avoid Heartworm. I have been hoping for years that, as with many human drugs, the costs will come down and/or a generic will be offered. And the years keep going by...
slt March 22nd, 2008 09:43:00 AM
I live in Ontario and have never know heartworm to be a risk to my indoor only cats. I'll have to discuss with my vet the next time I see him. I do know that all dogs I've had in the past have been on heartworm preventatives. So no new hole from me here.
Shannon
Shannon March 22nd, 2008 10:11:00 AM
We only see a positive heartworm dog every 18-24 months--but we recommend the year round control because most ALSO protect from roundworm, hookworm and whipworm. These not only cause pathology in your dog, roundworm and hookworm larvae can also infect people and cause fun stuff like visceral larval migrans. This means that worm larvae invade various human organs and cause a variety of problems--blindness if one wanders into your eye, liver or kidney problems, seizures if you get one in your brain. Fun stuff.
Preventing parasites in your pet also protects your health!
DrSteggy March 22nd, 2008 11:04:00 AM
I'm in PA, so I think that does make it a bit more complicated, because the risk is not as tremendous as in the South. We still recommend keeping dogs on preventative year-round, and that is what I do, though I do dose every 45 days over the winter instead of every 30. I absolutely believe there are risks to poisoning my dogs once a month. I believe the risks are much much higher if I do not.
katie March 22nd, 2008 11:52:00 AM
I don't use any heartworm preventative, because according to my research, there have been a whopping two reported cases of heartworm in my area in the last fifteen years, and both were in dogs who'd been recently transplanted from a more heartworm-friendly area.
Granted, if I lived in an area where heartworm was prevalent... I'd probably change my ways. :)
donna March 22nd, 2008 12:33:00 PM
I live in FL and it never fails to amaze me how many people don't use HWP. It isn't that expensive as far as medications go, and some vets can dispense it month by month if one can't afford to buy the whole pack at one time.
robyn March 22nd, 2008 01:58:00 PM
I have been struggling with whether to put my cats on heartworm preventative. They are indoor cats, but go out on the screened porch, and one of them seems determined to do enough damage to the screen to let some skeeters in.
I am really torn over the potential known and unknown risks or downstream effects of giving systemic medicines like this vs. the heartworm risk. I live in suburban Maryland - much less risk than Florida, but not none.
What to do?
Stefani March 22nd, 2008 02:35:00 PM
I am amazed and baffled over how many pet-owners tell me they don't treat for heartworm, citing that they never hear of it. My Scotties did not do well on heartguard years ago, but have no issue with interceptor. I too have been told that it is effective every 45 days vs. 30. I am not dosing my very, very elderly dog. But continue with Frontline for her.
I have tried Revolution on 9wk++ puppies, and I would love to buy that product for all my dogs, but can't afford that in "numbers"
Barb Albright March 22nd, 2008 04:08:00 PM
My guess is that these people have never had to put one of their pets through heartworm treatment? Angel came to us with it and we had to go through it. It wasn't a fun experience and I certainly won't be dealing with it again if I can help it.
My dogs are on Interceptor year round. I don't think it's really necessary but after all I went through with Angel I'm paranoid about it. My cats are strictly indoors and while it's possible that they could catch it from a stray mosquito making its way into the house, I haven't had a problem with them yet, so for now, no heartworm preventative for them.
I don't trust products like Revolution. I haven't heard anything really bad about it, but I can't wrap my brain around the fact that one med can take care of so many things all at once. I just don't feel that it would be completely effective, so I don't bother with it.
Stacy March 22nd, 2008 06:55:00 PM
My dogs have been on Revolution for years without any obvious problems. I say obvious because I don't know enough about the drug itself to know whether effects can be cumulative, what the symptoms might be, etc.
I trust my vet, so I use it. My new vet had us try Advantage II (I think) last year. I couldn't stand the smell, so I switched back to Revolution (since had enough left that was not stale-dated to see me through the season).
I live in Ontario, so we usually use the meds from the beginning of June until the end of October.
People say there's hardly any heartworm around (or sarcoptic mange, ear mites, and the other things Revolution addresses). I think that's because of quite high compliance with the meds around here.
It isn't cheap, around $100 or so for each my 3 small dogs (around 10 lbs each) but it's just the cost of owning a dog as far as I'm concerned.
I thought Revolution was relatively safe, since it's not an insecticide but a drug. Should I be concerned? Also, I get the blood test every year, although a friend said alternate years are fine. I figure for the $50 or so it costs I'd just as soon have it every year in case the previous year's lot of meds were ineffective. Is that overkill?
I'm not looking for curbside advice, btw, just asking :>)
Caveat March 22nd, 2008 08:57:00 PM
This is a summary of how selamectin works from the Merck manual. Sounds a bit brutal if you're a worm, but...
The macrocyclic lactones act by binding to glutamate-gated chloride channel receptors in nematode and arthropod nerve cells. This causes the channel to open, allowing an influx of chloride ions. Different chloride channel subunits may show variable sensitivity to macrocyclic lactones and different sites of expression, which could account for the paralytic effects of macrocyclic lactones on different neuromuscular systems at different concentrations. The macrocyclic lactones paralyze the pharynx, the body wall, and the uterine muscles of nematodes. Paralysis (flaccid) of body wall muscle may be critical for rapid expulsion, even though paralysis of pharyngeal muscle is more sensitive. As the macrocyclic lactone concentration decreases, motility may be regained, but paralysis of the pharynx and resultant inhibition of feeding may endure longer than body muscle paralysis and contribute to worm deaths. In filarial nematodes living in the tissues, females move very little and nutrients are absorbed through the cuticle. A major effect of macrocyclic lactones on adult worms of these species is probably paralysis of uterine muscles, resulting in disruption of reproduction. None of the macrocyclic lactones are active against cestodes or trematodes, presumably because these parasites do not have a receptor at a glutamate-gated chloride channel.
Here's some safety info on macrocyclic lactones scroll down:
http://www.merckvetmanual.com/mvm/index.jsp?cfile=...
I guess it's just risk/benefit analysis and as I say, I trust my vets. I haven't seen a flea since 1995.
Caveat March 22nd, 2008 09:21:00 PM
One option you might offer people who are concerned is to use a lower dosage of Interceptor (milbemycin oxime). The FDA has approved a dosage that is 1/5 the regular Interceptor dosage for heartworm prevention only (will not control intestinal parasites). The trade name, Safeheart, has never been marketed, but it's the same drug as is found in Interceptor, just a lower dose.
The recommended dosage of milbemycin oxime for heartworm prevention only is 0.05 mg per pound of body weight (0.1 mg per kg). Contrast this with the recommended dosage of Interceptor for control of heartworm and intestinal parasites: 0.23 mg milbemycin oxime per pound (0.5 mg/kg) of body weight. Heartworm can be prevented at a much lower dose than that needed to control intestinal parasites.
Safeheart contains 2.3 mg of milbemycin oxime for dogs from 2 to 50 pounds, and 5.75 mg for dogs 50 to 125 pounds. Interceptor contains 2.3 mg for dogs up to 10 pounds, and 5.75 mg for dogs 11 to 25 pounds. So if your dog weighs more than 50 pounds, you can give the Interceptor for dogs 11-25 pounds, otherwise you can use the one for dogs up to 10 pounds.
See http://www.fda.gov/cvm/FOI/1365.htm for the FDA summary on Safeheart.
Mary March 23rd, 2008 12:32:00 PM
"I can not afford the Heartworm meds you mention so I use (off label) an alternative. I would prefer to use the ones specifically made for dogs in nice little treat like pills. I guess either their costs are significantly greater to make those (as opposed to what I use) or their greed is significantly greater than their desire to help animals avoid Heartworm. I have been hoping for years that, as with many human drugs, the costs will come down and/or a generic will be offered. And the years keep going by..."
There are generics available - TriHeart, Iverhart, etc., that are significantly less expensive than Heartgard - although they may not be an "all in one" product and are still more expensive than using ivermectin labeled for livestock (not sure if that is your alternative or not - it's mine).
"Based on their read of the literature, they’re often inclined to rely on the studies describing adverse reactions..."
And therein lies the problem, I think. Not everyone can read studies printed in a medical journal and glean a full understanding of the text. For those who can, there is a vast difference between understanding the thesis of what you are reading and actually interpreting the data and applying it to real life. Veterinarians make their recommendations based upon what they read as well as what they've experienced clinically in practice, and that second factor is the difference between the validity of a veterinarian's recommendation and the preference of even the most well-informed, educated of clients.
I like owners who are well-informed, educated, and who do their own reading in an effort to provide the best care for their pets (I'm one of them) - but we need to understand our limitations when stacked up against those of a vet.
BTW, here in Oklahoma, where you can easily see 60-degree weather in January or December and ice the next day, and where the mosquitos (in my backyard, at least) reach plague-like proportions, year-round heartworm preventive is pretty much mandatory unless you enjoy the thrills of extreme betting, and if you'd rather use the plain old Heartgard as opposed to the newer Revolution, Advantage Multi, etc., fine - just use it!
anna March 23rd, 2008 01:33:00 PM
Here in Portland, Oregon, heartworm prevention is pretty much used as a travel medication. I use Advantix (which is very effective against mosquitoes here and generally considered sufficient heartworm prevention), but a couple years ago when I got a (clean) fecal exam for my dog just prior to traveling to Texas, the vet recommended that I just keep her on the heartworm meds to avoid general worm problems. I've followed the same protocol for my younger dog. While we still have low heartworm levels, other worms seem to be becoming more common. (Probably because over the counter wormers are becoming less commonly used.)
I can't imagine not doing something, although I know lots of people who don't. I generally try to get them to use Advantix because it's an easier sell and effective prevention here. Heartworm treatment is just too extreme to make prevention seem overwhelmingly risky, even in a low risk environment.
I recommend that you show photos of an open heart heartworm removal surgery to anyone in Miami who thinks it is too risky (although I don't think anyone does that anymore.)
Juli March 23rd, 2008 05:30:00 PM
"There are generics available - TriHeart, Iverhart, etc., that are significantly less expensive than Heartgard - although they may not be an "all in one" product and are still more expensive than using ivermectin labeled for livestock (not sure if that is your alternative or not - it's mine)."
Hi Anna,
Thank you for mentioning those other products - I had not heard of them. I guess the catch is that you can't get them unless you bring your dogs in for a yearly blood test *and* your Vet carries those products. Or unless you want to pay the extra "prescription fee" to have your Vet write you a prescription so you can order them from a catalog (maybe all Vets don't charge that fee, I don't know). In any case, I have been laid off 3 times since 2001 and although I never imagined myself in the economic situation I'm in now, I still must do the best I can for my 8 dogs. Being in the South, we need year round HW meds.
slt March 23rd, 2008 06:47:00 PM
Just out of curiosity-- how long after a negative HW test do you have to start heartgard? Mine were not on it over the winter, were tested in Jan and I completely forgot to buy them some until this entry! Am I okay just starting them now...or do I need to do another HW test?
Amanda March 23rd, 2008 10:19:00 PM
Amanda- If you live in a climate that has a winter, you shouldn't have to test again. Heartworm season in my neck of the woods (MA) is April- November.
Stacy March 24th, 2008 06:14:00 AM
That should say area, not climate.
Stacy March 24th, 2008 06:15:00 AM
Here in Florida we're obligated to test once a year. That's the standard of care here and throughout the Southeast. We usually start heartworm prevention immediately after a negative test. And though it causes us some ill-will among clients who swear up and down they've never missed a month, we require yearly testing.
Dr. Patty Khuly March 24th, 2008 11:14:00 AM
Dr. K, how does your clinic deal w/the following scenario:
A usually-compliant owner stops by to purchase some hwp - our records show that it has been 9 months since the owner last purchased hwp, and we have no indication that it was purchased elsewhere (the owner states he forgot to give doses the last three months). The pet is not technically "due" for its annual heartworm test yet. Do you go ahead and sell him the hwp and have his pet tested at the usual time of the year, informing the owner that his pet may have contracted heartworms that went untreated during the times he missed doses but that it wouldn't show up on the test today anyway? Or do you refuse to dispense the hwp until he brings his pet in to be tested and the test is neg. (which is to be expected, given that infection, if it happened, happened in the last three months)? While the last option follows the technical rule of not dispensing hwp until the pet has tested neg., it also delays a potential positive test result (and therefore treatment initiation) since the heartworm test performed today (earlier in the year than the pet's annual testing date) now grants the owner permission to purchase hwp for another 12 months before re-testing - except that the pet could potentially show positive mid-way through the year from doses missed in those three months.
We run into this a lot in my clinic, and I'm just curious as to how others handle it.
anna March 24th, 2008 12:45:00 PM
Anna - have a look at this
I have missed two months of heartworm prevention for my dog. Should I worry?
http://www.heartwormsociety.org/article.asp?id=14#...
As for me, I'm in southwestern BC where we have not seen any local heartworm. The only cases which pop up are in dogs which spent time in other areas. My sense is that most people who do not travel frequently, do not do hw prevention.....
hornblower March 24th, 2008 01:51:00 PM
hornblower- thanks for the link. Heartworm prevention is a tricky thing when you take into account veterinarian liability and manufacturer guarantees - even though the dog will probably be fine if you just resume the monthly dosing regimen, it's more the liability/guarantee thing (on the clinic side) that has me confused. FYI, our clinic follows the second option, but I just can't make sense out of it based on the very information your link also provides.
anna March 24th, 2008 08:01:00 PM
We live in Southern Ontario and we forego both flea and heartworm medications. In the two years of working in a local clinic, we saw not one positive heartworm case. We use a combination of tea tree oil sprays, neem oil sprays, and other natural products as insect repellents when we're in mosquito heavy areas, which is rare. We also test twice a year, spring and fall, and deworm with Panacur three times a year due to its level of safety.
My issue with heartworm "prevention" is that it's not prevention. It's treatment. It gives the consumer the idea that the product actually prevents the microfilariae from entering the dog. The reality is that the drug circulates the dog's system for up to six weeks (or longer) after ingestion and kills any microfilariae it encounters before they can develop into life-threatening worms.
Dewormers, flea prevention, four to seven yearly vaccinations, heartworm meds... I say this with the highest respect, Dr. Khuly, but if you were asked to give this to your child... would you?
I think if parents were told that there was a 2-5% chance that their child would be hit by a car and that they should buy a helmet, most parents wouldn't hesitate. If they were then told that chemicals from the helmet were absorbed by the child, and while the doctors and helmet companies assure us that they are safe, 1% of children have extremely bad reactions to helmets... and we really don't know what the long term effects of helmets ACTUALLY are.
Personally, I think there would be a lot of parents who would simply choose to ensure that their child drove their bike VERY, VERY carefully.
kim March 27th, 2008 10:53:00 AM
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