Vet School 101 Angel Eyes is for “little angels” (too bad the devil’s in the details)

Testimonials and positive reviews abound on the web when it comes to the product reserved for the eyes of our “little angels.” Owners of white pets everywhere swear by Angel Eyes. Those whose pets suffer marked tear stains caused by ruddy pigments called porphyrins are “amazed” by its results. All in all, it’s the end of the unsightly ocular dreeblies in a bottle. And it REALLY works.

A teaspoon or less of Angel Eyes in your dog or cat’s food or water bowl daily and a few weeks later––cue up the celestial soundtrack––no more ugly facial expressions caused by those pesky tears.

Never mind that tears can run down faces because eyes are misshapen. Never mind that the presence of excessive lacrimation is often evidence of disease. We have a cure for what ails you, suggests Angel Eyes, the look of sickliness is all but erased by our magic pixie dust.

God forbid we should actually explore the problem behind excessive tearing and its indelible staining...lest we find that our pets are afflicted by the genetic anomalies, ophthalmic diseases and/or poor hygiene that too often lead to a feline and canine “raccoon-eyed” appearance.

But the worst part is NOT that Angel Eyes is a quick fix to a basic problem of poor ocular conformation or a variety of other ophthalmic diseases. And it’s NOT that the presence of a product like Angel Eyes allows for breeders of Maltese dogs and Persian cats, among others, to continue to breed for unhealthy deformities and disease.

The real problem? Most users of Angel Eyes have no idea what they’re offering their pets by way of aesthetic maintenance. In case they really wanted to know, here’s a sampling of what the manufacturer offers on its website by way of explanation:

"Q. How does Angels' Eyes® work?

A. Angels’ Eyes works to prevent tear staining by tying up circulating porphyrins. A porphyrin is a compound that reacts with light to produce a reddish brown stain to the medial canthus. The ingredients in Angels' Eyes will prevent your dog from contracting Ptyrosporin (Red Yeast) and bacterial infections which causes excess tearing and staining.

Q. What are the ingredients in Angels' Eyes®?

A. Angels' Eyes is wheat and dye free, it's made of 100%Pure beef liver, tylosin as tartrate.

Q. What's the difference between Angels' Eyes® and all the other products on the market?

A. All other products mask or have artificial food coloring, artificial food additives and preservatives, and cereals such as wheat causing the stains to reappear worse than before. Angels' Eyes® does not require rubbing or any other difficult maintenance. With Angels' Eyes® you will not need to use bleach, peroxide or any other product that may cause allergies and irritations."

Angel Eyes is truly sent from heaven, any interested owner might glean, since it’s got “pure” stuff and is “wheat and dye free.” All other products are so “artificial” with all their “preservatives.”

Never mind that this product’s active ingredient is a macrolide antibiotic called tylosin.
Never mind that clearing up tear stains in this way means you’ve got to offer your dogs a daily dose of antbiotic for the rest of his natural life.
Never mind that Angel Eyes is illegal in Europe and other places where antibiotics are not readily allowed in products like this.
Never mind that while the rest of the world is looking for ways to curb bacterial resistance to antibiotics, Angel Eyes is promoting it...just so your dog can look “pretty” in the face of disease.

Remember how we discussed Obama’s proposals condemning the use of on antibiotics for non-therapeutic use in animals intended for our food supply? Most of you agreed that antibiotics should not be freely administered to our farm animals given that they facilitate the overcrowding of agriculture species and promote bacterial resistance to antibiotics sorely needed for human and animal health.

Angel Eyes offers a parallel scenario. But it’s legal. It’s also legal to offer your pets antibiotics you buy at the fish store. But would you?

Angel Eyes’ website clearly states that anyone considering starting any “supplement regimen” for pets should consult their veterinarian first. Good for them. (Though I think you’ll agree it’s a tad disingenuous to call any product containing an antibiotic a “supplement.”) Too bad I’ve yet to meet the first Angel Eyes user I didn’t have to prompt for info before I could ascertain the real reason behind the lack of tear staining.

Nope, I’ve never been consulted. Why? Because my clients had no earthly idea Angel Eyes contained an antibiotic. They had no clue their own pet was a test case for bacterial resistance. They had no inkling that it might make a difference for their own pet’s health to ask the vet. Nope, they were using it based on the seemingly innocuous advice of a friend, neighbor, breeder, Google, etc.

Go ahead. Search Google for “Angel Eyes and pets” and the bulk of what you’ll get is a lengthy list of places to shop...along with Maltese and poodle owners waxing poetic on the glories of the product. “And then the heavens opened up and gave me and my Pucci these Angel Eyes...just look at her.”

Effectiveness and heartfelt testimonials littering the web notwithstanding, the only thing I know for sure is that this product...she’s no angel. Here's hoping that with this post, future search engine research will unearth at least one more evangelical opinion on the subject...mine.

July 28th, 2009

Add Comment51 Comments

I've always considered the minor tear staining my white cat gets and the slightly worse tear staining my white dog gets to be a cosmetic issue. The idea of giving a daily dose of antibiotic for a cosmetic issue just struck me as obviously wrong.

But if people don't realize that Angel Eyes contains an antibiotic, they can't have that cautionary thought on their own. :(

More recently, as I've been home cooking for my dog, I started using spinach in some of her meals. I was just trying to increase the variety in her food with an eye toward ever-better nutrition. Completely to my surprise, I've found that when she has spinach in her meals for a few days running, the tear stains disappear. Other people have found that the tear stains vanish when they make sure there's no beet juice in any of the dogs' food. How much of tear staining is diet-related?

Lis July 28th, 2009 10:23:50 AM

Dr. K, are tear stains mainly a food issue? I have a white dog who had bad stains as a pup until we put her on a raw diet, no more stains.

Its entirely freaky that this product is an antibiotic!!!

Jen July 28th, 2009 11:37:26 AM

Reportedly very food related in some cases. Food allergies that allow for yeast infections have been postulated as the cause of the pigmentation for some. They're also related to eyes that are weepy by nature of their position in their socket or the configuration/location of the tear ducts. Inverted or everted lids along with any eye disease that causes excessive tearing can be responsible, too.

Dr. Patty Khuly July 28th, 2009 12:03:07 PM

I wonder about the above food related issues. Years ago, I noted certain foods would cause reddish-brown coat in my black dogs & switching made that go away.

I stuck with certain canned foods to keep my Sealys' beards white, lots of people asked me about their diet.

I had a Scot with one life-time blocked tear duct, but never stained on the black beard.

My real concern is when the eyes stop tearing, as that means trouble ahead, with the elderlys' eyes. Blepharitis is not uncommon in both canines & humans late in life. My Dottie went from high Schirmer tear test to horribly low , and needed Optimmune for her last year.

Barb A./NH July 28th, 2009 12:16:17 PM

I had no idea that angels eyes was an antibiotic - i currently am giving my frenchie a supplement for tear stains (not Angels Eyes and i got it free with a coupon when i bought ear cleaner). I'll have to take a closer look at the ingrediants.

The vet has checked her out and she's fine (as fine as a puppymill rescue can be) and she's on a great food , and the only reason i decided to try the free supplement was because sometimes her tear stains cause her a bit of itching.

Thanks for this post doc!

Sarah July 28th, 2009 12:17:24 PM

Interesting, I always have clients asking me where they can purchase this product because they have heard of it through a breeder/friend/internet. I've never had any luck finding it- I guess it's not available in Canada. Now I know to tell people that it's a bad idea anyway! I had no idea it is just Tylosin!

Meghan RAHT July 28th, 2009 12:19:09 PM

Thank you Dr. Khuly,

One of our local natural pet stores in SF won't carry Angel Eyes because of the ingredients and tries to educate people about it. A long overdue evaluation that will hopefully get more notice now!

Scary -- there's even a MSDS on tylosin tartrate -- http://www.sciencelab.com/xMSDS-Tylosin_Tartrate-9925378.

Tammy SF July 28th, 2009 12:48:54 PM

Enjoyed your rant. Most people today are seeking quick fixes for just about everything. It is a shame when it affects the behavior, health, and longivity of an animal--just wondering how we can facilitate change so that people will take the time to educate themselves and put a little work into providing a better life for their pets...they clearly want to but many fail when it comes to the follow through.

Ark Lady July 28th, 2009 01:31:45 PM

Always figured the tears/stains were a symptom and I don't like masking those. No beef, more spinach, less crud in food generally; tears and stains nearly gone. Some tears and stains when the air quality goes down and Ms. Shiba starts sneezing though.

Generally, I disagree on the over restriction of antibiotics but just dosing on a regular basis for something like this? That's absurd even in my book. I wouldn't have known tylosin was an antibiotic but, these days, I'd have looked it up before giving/using it.

This stuff could really add to the potential of an OD, couldn't it?

PJBoosinger July 28th, 2009 03:00:46 PM

I mostly advise clients to keep the tear tracks greased with vaseline or other bland hydrophobic material. Of course, the grease should not touch the eye itself. I make an analogy to the gutters and downspouts on a house which allow water to drain away without accumulating. I really don't know how many people follow my advice, but nobody has complained.

Dr. Steve Dubin July 28th, 2009 03:26:06 PM

I had no idea this product had antibiotics in it. Yikes! Thanks for this post!

Ingrid King July 28th, 2009 04:28:32 PM

I've yet to have a case of staining that did not clear with a tweek or shift in diet. Even if there's no tear staining, light colored dogs wil stain their chins or even feet if they tend to lick or lay their heads on their legs after drinking or panting.

Eyes that tear or drain excessively mean a trip to the vet.

BTW, I know the dog in your lead in picture, he's now 13, healthy if a little deaf but still fit and sound although he has a much longer stretch and warm up than when that picture was taken. Koit Cleaners still uses his picture in a carpet cleaning ad oiut here. A bit of a grumpy old man but he's earned that. :) I saw him last over the Fourth of July weekend, he came over demanded a scratch, then gave me a snort when no cookies were in the offing and moved on to the next mark.

JenniferJ July 28th, 2009 09:10:54 PM

How does this compare to using hand soaps/sanitizers containing Triclosan?

JCB July 28th, 2009 10:06:42 PM

It is not legal in the UK apparently. The reasoning behind this is set out here: http://www.bichonhotel.co.uk/cms/angelseyes

Alison (in Australia) July 29th, 2009 03:50:35 AM

Alison: That's an interesting point of view. Let me paraphrase to see if I got that right: It's terrible that Angel Eyes is no longer available in the UK since it won't harm your dog in any way. Too bad we'll now have to focus on preventing stains instead of removing them. What a revelation!

Dr. Patty Khuly July 29th, 2009 06:53:08 AM

double checked the ingredients on the stuff i have -

cranberry extract, marshmallow root, grape root and calcium ascorbate - no antibiotics.

Do you have to continuously use Angels Eyes to keep the stains away? the stuff i have is just a temporary supplement

Sarah July 29th, 2009 09:34:50 AM

Sarah: Yep. If you're not using any preventative measures you're going to need to give the stuff daily, though Angel Eyes' website claims that you can reduce to four times a week after a couple of months or so.

Dr. Patty Khuly July 29th, 2009 10:43:58 AM

Interesting development: My local Iams rep just informed me that some dogs respond well to probiotics for both prevention and treatment of lacrimal staining. It was something they discovered as a "side effect" of intestinal probiotic usage in pets that required chronic dosing.

Dr. Patty Khuly July 29th, 2009 12:05:19 PM

Huh. Thanks for this. I have a chronically crusty-eyed cat (dark reddish buildup). It doesn't seem to bother her in the least and the vet gave her a clean bill of health. My daily removal of the schmutz seems to bother her more than its presence. I think it's just how her eyes are set (slightly flatter than her littermate, with a more triangular face shape). I was considering Angel Eyes on the basis of "well she doesn't seem bothered... but she might be... it's not like she can tell me, right?" But up to this point everything I've read just left me a little uncomfortable. I was always left with the question "Yes, but WHY does it work?" I'll definitely just let it be.

AnneT July 29th, 2009 01:59:58 PM

AnneT and others: I'd like to amend my above comment on probiotics. It seems that the Prostora made by Iams works better than others. The Iams rep (consider the source) explained that this finding is only for Prostora and is as yet anecdotal. It has not been studied for its efficacy for this indication. It has been proven safe, though. The current recommendation is once daily for a couple of weeks then every third day thereafter. I, for one, would give it a try if I had white pets with nasty tear stains. It would never, however, replace basic hygiene.

Dr. Patty Khuly July 29th, 2009 06:18:11 PM

I've never heard of that product before however after one bad experience with a tear stain remover I'm leery of any of them now.

My oldest cat (now passed away) used to have horrible tear stains and of course her white markings were right where the staining was.

Her vet said it was a tear duct problem and since he didn't have the tools to do surgery on such a small animal I'd have to be refered to a specialist.

Since I didn't have that kind of money for a specialist for a basically cosmetic problem I declined.

Instead I found a tear stain remover from the catalogue of Dr's Foster & Smith. My vet wasn't familiar with that particular product but said it was probably ok to try it once he read the ingredients.

Well after only 1 1/2 weeks on the tear stain remover my cat got a horrible eye infection in both eyes. Something that had never happened before and she was about 13 years old at the time.

The vet gave her antibiotics and some ointment for her eyes, and concluded that it was the tear stain remover that caused the infection, although he didn't specify how.

I threw the bottle away and have since warned people away from using those things.

For the remainder of the life of my cat (she died at 17) I just used a saline solution to rinse out her eyes and she never had an eye infection again, although the staining never did go away either.

I'd rather have my pets healthy than pretty if given the choice.

cl July 29th, 2009 06:22:39 PM

Not to bore you, but... Here's what I got from the Iams rep just now:

Dr. Khuly,

Thank you for allowing me to present the information of Prostora MAX, our new Probiotic.

Attached is the information you asked about in regard to the reported observances with Prostora Max

As promised a few talking points around Prostora reducing tear staining:

IAMS has received a small number of reports from breeders and veterinarians indicating Prostora has a positive effect on reducing tear staining - reporting 80-90% success. Stain reduction occurred as quickly as 3 days to an extended period of six weeks. We do not have controlled data to validate the findings, nor an explanation of the mechanism of action. The following regimen has been reported to be successful in tear stain reduction: 1. Administer one Prostora supplement daily

2. Wipe the eyes daily with a moist cotton ball. The client will at first notice the cotton ball is stained (red) after wiping. Discoloration of the cotton ball will lessen and eventually clear.

3. Once the staining is cleared administered one Prostora supplement every third day.

I hope this helps.

Regards,

Richard

Dr. Patty Khuly July 29th, 2009 06:25:21 PM

Do you think they choose tylosin because it doesn't SOUND like an antibiotic? I mean, it's not a "cillin" or a "mycin," which most alert people might ID as an antibiotic. If I didn't know of it because of agricultural use, I would not know.

Or is the tylosin just the one that is effective?

I've never had occasion to use such a thing, and I don't expect I ever will, but thanks for the heads-up. I'll remember to ask clients who have little white dogs, etc., about "supplements."

H. Houlahan August 2nd, 2009 01:24:11 AM

Wow, this is great stuff. We don't carry Angel Eyes in our assortment at work. Now I can educate my customers about it, telling them how it works. They may or may not like what I'm telling them, but at least I'll know I've done my part. It's good to know about Iams too, I wonder if my rep would know this? (I'm guessing not), but it also helps to recommend a food that MAY help the staining.

Thanks Dr. K.

(PS: Saw you BARK, it was about Knees. Is the next issue going to have the Bloat information on it. I started a huge debate about raised feeding bowls at work and need to back it up now, LOL)

Thanks

Sharon August 2nd, 2009 07:18:58 PM

From my personal experience, I did not have to keep our dog on Angels' Eyes forever. A small amount daily over a two-week period and the tear stains were gone. It's been more than a year since I used Angels' Eyes. As with anything, use with moderation, monitor, follow directions. Did you have an experience with a patient who had a bad reaction to the product? What prompted the rant on this product?

Anna Cooke August 5th, 2009 08:24:19 AM

Dr. Patty said: "My local Iams rep just informed me that some dogs respond well to probiotics for both prevention and treatment of lacrimal staining."

Probiotics, oddly enough,can reduce symptoms of allergic rhinitis: http://www.ncbi.nlm.nih.gov/pubmed/19119700 and may play a role in infants developing asthma in later life: http://featuresblogs.chicagotribune.com/features_julieshealthclub/2007/06/antibiotics_up_.html

And here may be the clue as to how probiotics and perhaps even tylosin work on tear stains- by healing the gut: http://marvistavet.com/html/body_tylosin.html "In small animals, tylosin is not used as an antibiotic at all but as an anti-inflammatory. Its chief use is for the treatment of colitis. Here, it is not used as an antibiotic to treat infection but instead as an anti-inflammatory to soothe the large intestine.

As for Angel Eyes, I once wrote the people at the website and ranted at them. They're defensive and completely believe in administering unregulated unknown quantities of antibiotcs. One could call them downright hostile. I WISH THE FDA WOULD SHUT THEM DOWN!

CathyA August 5th, 2009 05:26:32 PM

Wow. I would never consider giving my cats ANYTHING supplemental without consulting my vet. I just wouldn't. I have some white cats, and they get the staining. I just wipe their faces and check with the vet if it seems excessive.

This is kind of scary to me.

Jen M. August 25th, 2009 12:08:17 PM

I use Eye Envy as it is a topical and it seems to work okay without any side effects or antibiotics. I have used their products on my blue eye white cats for a while and seems okay and works effectively.

Ashley September 12th, 2009 02:45:46 AM

Wow, I just got my new precious baby (he's a white pomeranian named Arthur) and was wondering about the tear stains. I just wipe his eyes with a natural baby wipe. I was wondering about the tear stains and saw something about Angel Eyes... Thank you for posting this now I know to steer clear! I was going to ask my vet about it when I see them tomorrow but forget that, I just won't buy. :)

Devan September 29th, 2009 06:04:23 AM

Wow... We carry Angel Eyes at my shop... This is concerning. I will recommend other things now! Thanks for the article!

Munchichi October 19th, 2009 05:09:31 PM

My pup came to me with an ear infection and a bronchial infection, not to mention TEAR STAINS. I did try everything I could find including Angel Eyes. The Angel Eyes was the only thing that worked. My pup was on it for two months. She is completely stain free and has had no reoccurrance of stains. She is no longer on Angel Eyes either, which counters the claim that pets have to be on it for the rest of their lives.

In helping her stay that way, she eats a raw diet with high quality grain free kibble., no additives, dyes or by products. Her food and water dishes are ceramic. She gets filtered water. Her facial hair gets trimmed regularly to prevent eye poking, and her ears are cleaned every week as well.

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Why exactly is it banned in Europe, and which particular country?

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